<div data-page-id="doxcnzfrnYhhLgEevEzQvlTKdqb" data-docx-has-block-data="true"> <div class="ace-line ace-line old-record-id-doxcneqKSCkg0cKIsQRBpq1pFjd"><span class="p">根據(jù)一項(xiàng)新的研究，血液測(cè)試可以通過(guò)識(shí)別血細(xì)胞產(chǎn)生的變化來(lái)提前幾年預(yù)測(cè)老年人群中患白血病的風(fēng)險(xiǎn)。</span></div> <div class="ace-line ace-line old-record-id-doxcnGSoGGQsi4ywS6MwjNZ6Efh"><span class="p">&nbsp;</span></div> <div class="image-uploaded gallery old-record-id-doxcnkyYGiyaQYWOoIRnpw6M4ce" style="text-align: justify;" data-type="image" data-ace-gallery-json="{&quot;items&quot;:[{&quot;uuid&quot;:&quot;219c4b49-c369-4783-9c9e-290b83e24c9c&quot;,&quot;height&quot;:480,&quot;width&quot;:720,&quot;currHeight&quot;:480,&quot;currWidth&quot;:720,&quot;natrualHeight&quot;:480,&quot;natrualWidth&quot;:720,&quot;pluginName&quot;:&quot;imageUpload&quot;,&quot;scale&quot;:1,&quot;src&quot;:&quot;https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2FboxcnK0Wxp9iXp2TGGm8CRdXB9b%2F%3Fmount_node_token%3DdoxcnkyYGiyaQYWOoIRnpw6M4ce%26mount_point%3Ddocx_image&quot;,&quot;file_token&quot;:&quot;boxcnK0Wxp9iXp2TGGm8CRdXB9b&quot;,&quot;image_type&quot;:&quot;image/jpeg&quot;,&quot;size&quot;:72553,&quot;comments&quot;:[]}]}"><span class="p"><img src="https://info.compassedu.hk/sucai/content/1658387324038/1658387324038.png" width="808" height="538" /></span></div> <div class="ace-line ace-line old-record-id-doxcnUosqMucuQISAEb7v565F9c"><span class="p">專家說(shuō)，通過(guò)識(shí)別風(fēng)險(xiǎn)最大的人，應(yīng)該有可能在未來(lái)提供預(yù)防性或早期治療，以改善患者的預(yù)后。</span></div> <div class="ace-line ace-line old-record-id-doxcna4gQ6S44GmMayeSwpGGMsf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcncIiyiAKsMy4qqYvPTw7mdd"><span class="p">白血病通常是血細(xì)胞生產(chǎn)中精細(xì)平衡中斷的結(jié)果，其中制造新細(xì)胞而舊血細(xì)胞死亡。</span></div> <div class="ace-line ace-line old-record-id-doxcn4CeS6ywGMIOw437Pqwxd4g"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnWG2aw2K0wKUM6wwrNTMs9f"><span class="p">隨著年齡的增長(zhǎng)，血液干細(xì)胞的突變可能意味著改變的細(xì)胞可以比其他血細(xì)胞具有生長(zhǎng)益處，并且在所謂的健身優(yōu)勢(shì)方面超過(guò)它們。</span></div> <div class="ace-line ace-line old-record-id-doxcnO4SAgGkmo0w6oPSSPPA8yb"><span class="p">&nbsp;</span></div> <h2 class="heading-2 ace-line old-record-id-doxcnGWs2aiioimC4aSvyYyx3Xb"><span class="p">調(diào)查更改</span></h2> <div class="ace-line ace-line old-record-id-doxcnAYqEEmuSSyMUqOC9vVfOGe"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnqsiAE86C8yC8G5wrWJ8H73"><span class="p">來(lái)自愛丁堡大學(xué)和格拉斯哥大學(xué)的研究人員調(diào)查了血液生產(chǎn)中發(fā)生的適應(yīng)性優(yōu)勢(shì)的變化如何根據(jù)發(fā)生的突變類型為患白血病的風(fēng)險(xiǎn)提供線索。</span></div> <div class="ace-line ace-line old-record-id-doxcnEwUmioKkIgm4stQzpRakBc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <blockquote class=" old-record-id-doxcnuEEeSQCqAOCUwP7jx52D6W" data-type="quote_container"> <div class="ace-line ace-line old-record-id-doxcnq2iKIOmU0aoYeONxOjJrue" style="text-align: justify;"><em><span class="h6">我們測(cè)量了洛錫安出生隊(duì)列中83名老年人血液樣本的變化，在12年內(nèi)每三年采集一次。利用數(shù)學(xué)家，生物學(xué)家和基因組科學(xué)家的綜合知識(shí)，我們開始了解這些變化對(duì)我們隨著年齡增長(zhǎng)而患白血病的風(fēng)險(xiǎn)意味著什么。</span></em></div> <div class="ace-line ace-line old-record-id-doxcnk4Mc2aayQcKcuYiG3tlkVd" style="text-align: justify;"><em><span class="h6">&nbsp;</span></em></div> <div class="ace-line ace-line old-record-id-doxcnU44gOYQkY8CCIDuvotq50f" style="text-align: justify;"><em><span class="h6">塔米爾&middot;錢德拉博士愛丁堡大學(xué)MRC人類遺傳學(xué)系校長(zhǎng)研究員</span></em></div> </blockquote> <div class="ace-line ace-line old-record-id-doxcn6EyoUOOIgWIeW2vj3uQ70e"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcniS6COYyqIuSqozZRmWR2dh"><span class="p">Lothian Birth Cohorts 1921和1936是對(duì)大腦，認(rèn)知和一般衰老的縱向研究，每3年對(duì)1921年70至82歲的個(gè)體和1936年的79至92歲之間的個(gè)體進(jìn)行隨訪。</span></div> <div class="ace-line ace-line old-record-id-doxcniEMs68wCgKUIxz0SkJ617J"><span class="p">&nbsp;</span></div> <h3 class="heading-3 ace-line old-record-id-doxcnIYiQQcoGiC2oUDNGjIJwzh"><span class="p">突變</span></h3> <div class="ace-line ace-line old-record-id-doxcn4qc8wU0SW2QIu1GpOMBxcb"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcni6GsYqoakmgmOYPhB3XWfh"><span class="p">然后，該團(tuán)隊(duì)將這些復(fù)雜的基因組數(shù)據(jù)與機(jī)器學(xué)習(xí)算法相結(jié)合，將不同的突變與攜帶這些突變的血液干細(xì)胞的不同生長(zhǎng)速度聯(lián)系起來(lái)。</span></div> <div class="ace-line ace-line old-record-id-doxcnWgYsW6QGU0gUmE6qAftlrf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcncMosqWsCmGI82bxWHcNwnh"><span class="p">研究發(fā)現(xiàn)，特定的突變?yōu)樵跊](méi)有白血病的人中測(cè)量的干細(xì)胞提供了明顯的適應(yīng)性優(yōu)勢(shì) - 這可以用來(lái)預(yù)測(cè)突變細(xì)胞生長(zhǎng)的速度，這決定了白血病的風(fēng)險(xiǎn)。</span></div> <div class="ace-line ace-line old-record-id-doxcn420yA8sESWOY0u1KwXB3Xf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnY6OKymckc4cMgNSrxRls8f"><span class="p">該團(tuán)隊(duì)表示，由于當(dāng)前研究中的樣本量有限，需要進(jìn)一步的研究來(lái)驗(yàn)證這些結(jié)果在更大的人群中。</span></div> <div class="ace-line ace-line old-record-id-doxcnSiw6IMemA4wgS4SFl87z2b"><span class="p">&nbsp;</span></div> <blockquote class=" old-record-id-doxcnKmSe8cU4QIKoaKuMTQOT1c" data-type="quote_container"> <div class="ace-line ace-line old-record-id-doxcniAGYge2GUKeSU7ATcoQ5Qb" style="text-align: justify;"><span class="h6">在了解個(gè)體患者患白血病的風(fēng)險(xiǎn)后，臨床醫(yī)生可以安排那些最有可能患上這種疾病的人的預(yù)約間隔更短，并提供早期治療，這更有可能成功。</span></div> <div class="ace-line ace-line old-record-id-doxcnOGgecueEaUiQiyy00F5r5c" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIkg6yuAMSG6s0rwKoYJXhb" style="text-align: justify;"><span class="h6">克里斯蒂娜&middot;基爾希納博士共同主要作者，格拉斯哥大學(xué)癌癥科學(xué)研究所高級(jí)講師</span></div> <div class="ace-line ace-line old-record-id-doxcnOSeK8sCqS2sA8gbpBIGxGc" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnsuuaIUGU4OIGYBfMfFquQe" style="text-align: justify;"><span class="h6">為了了解白血病的風(fēng)險(xiǎn)，我們需要考慮參與血細(xì)胞生產(chǎn)的不同細(xì)胞之間的平衡，以及這種平衡如何隨著年齡的增長(zhǎng)而變化。通過(guò)將基因組數(shù)據(jù)與機(jī)器學(xué)習(xí)聯(lián)系起來(lái)，我們已經(jīng)能夠根據(jù)血細(xì)胞產(chǎn)生的突變來(lái)預(yù)測(cè)它們的未來(lái)行為。</span></div> <div class="ace-line ace-line old-record-id-doxcnImcCuY4ScEiwmeG9BVEg8b" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnu08CcuUMk4GCEpUXelEnWg" style="text-align: justify;"><span class="h6">萊納斯&middot;舒馬赫博士愛丁堡大學(xué)再生醫(yī)學(xué)中心的共同主要作者和校長(zhǎng)研究員</span></div> </blockquote> <div class="ace-line ace-line old-record-id-doxcnOEIc44O6g6qiiKPuiscZlc"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIIaeEAwcSsaeq2XjCDgssg"><span class="p">這些發(fā)現(xiàn)已發(fā)表在《自然醫(yī)學(xué)》雜志上。這項(xiàng)研究由醫(yī)學(xué)研究委員會(huì)，英國(guó)白血病和英國(guó)癌癥研究中心資助。</span></div> <div class="ace-line ace-line old-record-id-doxcnoYw28GYmgyYGMz5vAZpUgQ"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnQMsYoCgsUQAsOsFZwJJW5d"><span class="p">Lothian Birth隊(duì)列獲得生物技術(shù)和生物科學(xué)研究委員會(huì)，經(jīng)濟(jì)和社會(huì)研究委員會(huì)，Age UK，Wellcome，皇家學(xué)會(huì)，醫(yī)學(xué)研究委員會(huì)和愛丁堡大學(xué)的資助。</span></div> </div>