香港浸會(huì)大學(xué)教授發(fā)現(xiàn)孕期PM2.5暴露造成小鼠胎兒細(xì)胞和器官水平不同程度的代謝紊亂
指南者留學(xué) 2023-05-19 14:48:05 閱讀量:1356
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box-sizing: border-box;"> <section style="text-align: justify; font-size: 22px; padding: 0px 15px; box-sizing: border-box;"> <p style="text-align: center; margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;蔡宗葦教授</p> </section> </section> <section style="text-align: center; margin: 0px 0px 10px; box-sizing: border-box;"> <section style="display: inline-block; width: 120px; height: 10px; vertical-align: top; overflow: hidden; background-color: #1a3b91; box-sizing: border-box;"> <section style="text-align: right; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> <section style="text-align: center; box-sizing: border-box;"> <section style="padding: 0px 25px; font-family: PingFangSC-ultralight; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="box-sizing: border-box;">香港浸會(huì)大學(xué)</span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="box-sizing: border-box;">化學(xué)系講座教授</span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="box-sizing: border-box;">環(huán)境與生物分析國(guó)家重點(diǎn)實(shí)驗(yàn)室主任</span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">二噁英分析實(shí)驗(yàn)室主任</p> </section> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; 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padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">香港浸會(huì)大學(xué)(浸大)化學(xué)系講座教授、環(huán)境與生物分析國(guó)家重點(diǎn)實(shí)驗(yàn)室主任、二噁英分析實(shí)驗(yàn)室主任<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">蔡宗葦教授</strong></span>,廈門(mén)大學(xué)<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">董繼揚(yáng)教授</strong></span>及中國(guó)科學(xué)院深圳先進(jìn)技術(shù)研究院<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">趙超副研究員</strong></span>共同領(lǐng)導(dǎo)的研究團(tuán)隊(duì),發(fā)現(xiàn)<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">孕期PM2.5暴露造成小鼠胎兒細(xì)胞和器官水平不同程度的代謝紊亂</strong></span><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #42403f; box-sizing: border-box;">研究成果發(fā)表于綜合性學(xué)術(shù)期刊</span><strong style="box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;">《iScience》</span></strong><span style="color: #1a3b91; box-sizing: border-box;"><span style="color: #42403f; box-sizing: border-box;">。</span></span></p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 443px; box-sizing: border-box; height: 489px;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392429096.jpeg" width="443" height="489" data-ratio="1.103448275862069" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392429096.jpeg" data-w="580" /></section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(-10px, 0px, 0px);"> <section style="text-align: justify; padding: 0px 15px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">?</span><span style="color: #42403f; box-sizing: border-box;"><span style="font-size: 12px; box-sizing: border-box;">&nbsp;相關(guān)</span><span style="font-size: 12px; box-sizing: border-box;">研究成果已發(fā)表于綜合性學(xué)術(shù)期刊《iScience》。</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0px 15px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 32px; line-height: 1; padding: 0px; color: #1a3b91; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #f7f7f7; background-color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">&nbsp;01&nbsp;</strong></span></p> </section> </section> <section style="text-align: left; margin: 0px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 22px; line-height: 2; padding: 0px; color: #42403f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">PM2.5</strong></em></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">隱形的</strong><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">健康「殺手」</strong></span></em></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0% 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 95%; height: auto; box-shadow: #1a3b91 12px 12px 0px; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 448px; box-sizing: border-box; height: 278px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392154620.jpeg" width="448" height="278" data-ratio="0.6203703703703703" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392154620.jpeg" data-w="1080" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">PM2.5是指大氣中直徑小于或等于2.5微米的顆粒物</strong></span>,也稱(chēng)為可入肺顆粒物。PM2.5作為常見(jiàn)污染物,對(duì)人體健康存在危害。世衛(wèi)組織曾指出:當(dāng)PM2.5年均濃度達(dá)到每立方米35微克時(shí),人類(lèi)<span style="color: #42403f; box-sizing: border-box;">的死亡風(fēng)險(xiǎn)比每立方米10微克的情形增加約15%。</span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">浸大協(xié)作研究發(fā)現(xiàn),<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">懷孕時(shí)接觸大氣細(xì)顆粒物(PM2.5)可能導(dǎo)致胎兒認(rèn)知行為障礙以及多器官損傷。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">利用<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">質(zhì)譜成像(Imaging Mass Spectrum,IMS)的空間組學(xué)技術(shù)</strong></span>,團(tuán)隊(duì)成員在接近細(xì)胞分辨率的層面上分析分子特性,觀(guān)察不同器官的代謝物含量及其相關(guān)性,進(jìn)而闡明PM2.5對(duì)胚胎代謝和發(fā)育的影響和機(jī)制。目前該技術(shù)已被廣泛應(yīng)用于<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">環(huán)境毒理研究</strong></span>。</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: left; margin: 0px 0px 15px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 32px; line-height: 1; padding: 0px; color: #1a3b91; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #f7f7f7; background-color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">&nbsp;02&nbsp;</strong></span></p> </section> </section> <section style="text-align: left; margin: 0px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 22px; line-height: 2; padding: 0px; color: #42403f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;"><em style="box-sizing: border-box;">器官之間的</em></strong></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><strong style="box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;">代謝物相關(guān)性</span></em></strong><strong style="box-sizing: border-box;"><em style="box-sizing: border-box;">顯著增強(qiáng)</em></strong></p> </section> </section> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 538px; box-sizing: border-box; height: 315px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392775726.jpeg" width="538" height="315" data-ratio="0.5853658536585366" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392775726.jpeg" data-w="902" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">? <span style="color: #42403f; box-sizing: border-box;">研究人員將懷孕小鼠分為兩組,一組接觸PM2.5,另一組則不接觸。</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">研究人員將懷孕小鼠分為兩組,一組接觸PM2.5,另一組則不接觸。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">接觸PM2.5的小鼠胎兒中,大部分器官之間的代謝物相關(guān)性得到顯著增強(qiáng),表明小鼠胎兒體內(nèi)的不同器官在環(huán)境變化時(shí),原本不同的代謝過(guò)程和產(chǎn)物會(huì)趨于一致。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">此外,與健康對(duì)照組相比,接觸PM2.5使得心臟和肝臟以及心臟和小腸之間的代謝更為相似,而使得肝臟和胸腺之間的代謝更為不同。</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 439px; box-sizing: border-box; height: 195px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392540933.jpeg" width="439" height="195" data-ratio="0.44461538461538463" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392540933.jpeg" data-w="650" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: justify; padding: 0px 20px; font-size: 12px; font-family: Optima-Regular, PingFangTC-light; color: #42403f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">? 在接觸PM2.5的小鼠中,心臟和肝臟、心臟和小腸之間的代謝更為相似,肝臟和胸腺之間的代謝更為不同。</p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: left; margin: 0px 0px 15px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 32px; line-height: 1; padding: 0px; color: #1a3b91; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #f7f7f7; background-color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">&nbsp;03&nbsp;</strong></span></p> </section> </section> <section style="text-align: left; margin: 0px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 22px; line-height: 2; padding: 0px; color: #42403f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">部分器官的代謝</strong></em></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">更易受PM2.5影響</strong></em></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">研究人員推測(cè),小鼠胎兒通過(guò)代謝重編程,構(gòu)建起了細(xì)胞間和器官間新的代謝穩(wěn)態(tài),并以此對(duì)應(yīng)孕期接觸PM2.5產(chǎn)生的不良影響。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">因此,研究人員以健康組小鼠的器官作為參考,分析接觸PM2.5的小鼠體內(nèi)各器官代謝的受影響程度。<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">結(jié)果顯示,接觸PM2.5的小鼠體內(nèi)的器官在不同程度上導(dǎo)致了代謝物含量及其相互作用的變化,且兩個(gè)方面的變化趨勢(shì)一致。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">接觸PM2.5對(duì)各器官的影響程度從高到低依次為:胸腺、肝臟、腦、海馬結(jié)構(gòu)、肺、心臟和腸。</strong></span></p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 509px; box-sizing: border-box; height: 482px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/168448139295900.jpeg" width="509" height="482" data-ratio="0.9467889908256881" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/168448139295900.jpeg" data-w="545" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">? </span><span style="color: #42403f; font-size: 12px; box-sizing: border-box;">器官受PM2.5影響程度從高到低依次為:胸腺、肝臟、腦、海馬結(jié)構(gòu)、肺、心臟和腸。</span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0px 15px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 32px; line-height: 1; padding: 0px; color: #1a3b91; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #f7f7f7; background-color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">&nbsp;04&nbsp;</strong></span></p> </section> </section> <section style="text-align: left; margin: 0px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 22px; line-height: 2; padding: 0px; color: #42403f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">PM2.5或使</strong></em><span style="color: #1a3b91; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">器官代謝失衡</strong></em></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0% 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 95%; height: auto; box-shadow: #1a3b91 12px 12px 0px; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 580px; box-sizing: border-box; height: 389px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392823215.jpeg" width="580" height="389" data-ratio="0.6714727085478888" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392823215.jpeg" data-w="971" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">為全面了解PM2.5對(duì)各器官內(nèi)部代謝穩(wěn)態(tài)的影響,研究人員通過(guò)對(duì)兩種熵的分析,評(píng)估器官內(nèi)代謝穩(wěn)態(tài)的受擾動(dòng)情況。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">分析結(jié)果顯示,接觸PM2.5會(huì)引起小鼠胎兒各器官不同程度的代謝紊亂,這是PM2.5暴露誘發(fā)全身性疾病的重要原因之一;相對(duì)于其它器官,胸腺的代謝改變最顯著,其次是肝臟。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">這意味著,接觸PM2.5可能引起各器官代謝物相關(guān)性的破壞。另外,在接觸PM2.5后,各器官內(nèi)代謝的變化范圍明顯擴(kuò)大,即一部分代謝物含量更加紊亂的現(xiàn)象另一部分代謝產(chǎn)物含量趨于一致的現(xiàn)象同時(shí)存在,表明代謝物間的調(diào)控失衡。</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; margin: 15px 0px 25px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-image: linear-gradient(to right bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 0) 70%, rgba(26, 59, 145, 0.96) 70%, rgba(26, 59, 145, 0.96) 100%); height: auto; padding: 0px 10px 10px; box-sizing: border-box;"> <section style="margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 100%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 100%; box-sizing: border-box; height: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392116389.jpeg" width="758" height="242" data-ratio="0.3194444444444444" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392116389.jpeg" data-w="1080" /></section> </section> </section> </section> <section style="text-align: left; box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 20px; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="font-size: 12px; color: #1a3b91; box-sizing: border-box;">? <span style="color: #42403f; box-sizing: border-box;">接觸PM2.5會(huì)引起小鼠胎兒各器官不同程度的代謝紊亂</span></span></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0px 15px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 32px; line-height: 1; padding: 0px; color: #1a3b91; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #f7f7f7; background-color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">&nbsp;05&nbsp;</strong></span></p> </section> </section> <section style="text-align: left; margin: 0px; box-sizing: border-box; transform: translate3d(11px, 0px, 0px);"> <section style="font-size: 22px; line-height: 2; padding: 0px; color: #42403f; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">PM2.5暴露</strong></em></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">增加<span style="color: #1a3b91; box-sizing: border-box;">胚胎發(fā)育異常</span>風(fēng)險(xiǎn)</strong></em></p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0% 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 95%; height: auto; box-shadow: #1a3b91 12px 12px 0px; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 513px; box-sizing: border-box; height: 289px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392431996.jpeg" width="513" height="289" data-ratio="0.5623869801084991" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392431996.jpeg" data-w="553" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="justify-content: flex-start; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; box-sizing: border-box;"> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">研究發(fā)現(xiàn),<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">孕期PM2.5暴露造成小鼠胎兒細(xì)胞和器官水平不同程度的代謝紊亂。</strong></span></p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">PM2.5暴露顯著減弱了心臟-肝臟以及心臟-腸之間的代謝特異性,增強(qiáng)了肝臟-胸腺之間的代謝特異性,并且腦、胸腺和腦部海馬區(qū)在應(yīng)對(duì)PM2.5暴露時(shí)具有最強(qiáng)的代謝協(xié)同性。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">該研究提出了基于IMS數(shù)據(jù)的<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">多尺度網(wǎng)絡(luò)策略(iMS2Net)</strong></span>,闡釋了小鼠胚胎應(yīng)對(duì)PM2.5暴露的多器官代謝協(xié)同反應(yīng),對(duì)進(jìn)一步<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">探究PM2.5等常見(jiàn)污染物對(duì)機(jī)體的影響</strong></span>有重要意義,能夠啟發(fā)有關(guān)環(huán)境污染物毒性新機(jī)制的研究。</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> <section style="text-align: center; margin: 0px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 10%; height: auto; box-sizing: border-box;"><img style="vertical-align: middle; max-width: 100%; width: 100%; box-sizing: border-box; height: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392641407.jpeg" width="78" height="71" data-ratio="0.9166666666666666" data-w="1080" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392641407.jpeg" /></section> </section> <section style="display: flex; flex-flow: row nowrap; text-align: center; justify-content: center; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; flex: 0 0 auto; align-self: flex-start; height: auto; box-sizing: border-box;"> <section style="display: flex; flex-flow: row nowrap; margin: 0px 0px 5px; opacity: 1; justify-content: center; box-sizing: border-box;"> <section style="display: inline-block; width: auto; vertical-align: middle; flex: 0 0 auto; align-self: center; min-width: 10%; max-width: 100%; height: auto; padding: 0px 0px 0px 2px; box-sizing: border-box;"> <section style="margin: 10px 0px 0px; box-sizing: border-box;"> <section style="font-size: 26px; color: #1a3b91; line-height: 1.6; box-sizing: border-box;"> <p style="text-align: left; margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">環(huán)境與生物分析</strong></em></p> <p style="text-align: left; margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">國(guó)家重點(diǎn)實(shí)驗(yàn)室</strong></em></p> </section> </section> </section> </section> </section> </section> <section style="margin: 0px; opacity: 0.58; box-sizing: border-box;"> <section style="font-size: 12px; line-height: 1.5; box-sizing: border-box;"> <p style="text-align: center; margin: 0px; padding: 0px; box-sizing: border-box;">State Key Laboratory of&nbsp;</p> <p style="text-align: center; margin: 0px; padding: 0px; box-sizing: border-box;">Environmental and Biological Analysis</p> </section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; margin: 0px 0% 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 95%; height: auto; box-shadow: #1a3b91 12px 12px 0px; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 496px; box-sizing: border-box; height: 200px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392156450.jpeg" width="496" height="200" data-ratio="0.40370370370370373" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392156450.jpeg" data-w="1080" /></section> </section> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <section style="text-align: left; justify-content: flex-start; display: flex; flex-flow: row nowrap; margin: 10px 0px; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: rgba(62, 62, 62, 0.04); padding: 31px; box-sizing: border-box;"> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; color: #3e3e3e; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">2013年7月,浸大獲香港特別行政區(qū)政府創(chuàng)新科技署推薦,經(jīng)國(guó)家科學(xué)技術(shù)部批準(zhǔn),設(shè)立<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">「環(huán)境與生物分析國(guó)家重點(diǎn)實(shí)驗(yàn)室」</strong></span>(以下簡(jiǎn)稱(chēng)「實(shí)驗(yàn)室」)。</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: center; justify-content: center; display: flex; flex-flow: row nowrap; box-sizing: border-box;"> <section style="display: inline-block; width: 90%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; height: auto; box-sizing: border-box;"> <section style="margin: 10px 0%; box-sizing: border-box;"> <section style="display: inline-block; width: 100%; vertical-align: top; overflow: hidden; align-self: flex-start; box-sizing: border-box;">&nbsp;</section> </section> <section style="text-align: justify; font-size: 14px; color: #ffffff; font-family: Optima-Regular, PingFangTC-light; line-height: 1.5; padding: 0px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="background-color: #1a3b91; box-sizing: border-box;">實(shí)驗(yàn)室擁有多臺(tái)新型檢測(cè)儀器及裝置</span></em></p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> <section style="text-align: justify; color: #3e3e3e; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">實(shí)驗(yàn)室結(jié)合浸大及內(nèi)地合作實(shí)驗(yàn)室在<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">持久性有機(jī)污染物(POPs)</strong></span>分析方面的多年研究經(jīng)驗(yàn)及基礎(chǔ),建立以多組學(xué)、生物傳感及成像為重點(diǎn)的生物分析平臺(tái),針對(duì)POPs的分析測(cè)試提出新原理、建立新方法和新技術(shù),研制新型檢測(cè)儀器或裝置,<span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">為提高國(guó)家環(huán)境質(zhì)量和健康水平及履行國(guó)際公約提供科學(xué)和技術(shù)支撐。</strong></span></p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 90%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 461px; box-sizing: border-box; height: 308px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/168448139272424.jpeg" width="461" height="308" data-ratio="0.6666666666666666" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/168448139272424.jpeg" data-w="687" /></section> </section> <section style="text-align: justify; font-size: 14px; color: #ffffff; font-family: Optima-Regular, PingFangTC-light; line-height: 1.5; padding: 0px 15px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="background-color: #1a3b91; box-sizing: border-box;">蔡宗葦教授擔(dān)任環(huán)境與生物分析國(guó)家重點(diǎn)實(shí)驗(yàn)室主任</span></em></p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; color: #3e3e3e; font-family: Optima-Regular, PingFangTC-light; padding: 0px 20px; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">在實(shí)驗(yàn)室主任蔡宗葦教授的帶領(lǐng)下,實(shí)驗(yàn)室定期舉辦高質(zhì)量的國(guó)際研討會(huì),累計(jì)在全球知名國(guó)際專(zhuān)業(yè)期刊發(fā)表論文逾600篇。</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> <p style="margin: 0px; padding: 0px; box-sizing: border-box;"><span style="color: #1a3b91; box-sizing: border-box;"><strong style="box-sizing: border-box;">近年實(shí)驗(yàn)室更將研究聚焦環(huán)境污染、生命健康等普羅大眾生活息息相關(guān)的課題</strong></span>,研究成果包括揭示雙酚S暴露可能增加患癌風(fēng)險(xiǎn),以及發(fā)現(xiàn)腸道微生物酶與結(jié)腸炎之間的關(guān)聯(lián)等。</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: center; margin-top: 10px; margin-bottom: 10px; line-height: 0; box-sizing: border-box;"> <section style="max-width: 100%; vertical-align: middle; display: inline-block; line-height: 0; width: 90%; height: auto; box-sizing: border-box;"><img class="rich_pages wxw-img" style="vertical-align: middle; max-width: 100%; width: 488px; box-sizing: border-box; height: 326px; display: block; margin-left: auto; margin-right: auto;" src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392167915.jpeg" width="488" height="326" data-ratio="0.6666666666666666" data-src="https://editor-user.365editor.com/wechat/98/28/4941828/1684481392167915.jpeg" data-w="1080" /></section> </section> <section style="box-sizing: border-box; transform: translate3d(5px, 0px, 0px);"> <section style="text-align: right; padding: 0px 15px; font-size: 14px; color: #ffffff; line-height: 1.5; box-sizing: border-box;"> <p style="text-align: justify; margin: 0px; padding: 0px; box-sizing: border-box;"><span style="background-color: #1a3b91; box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="box-sizing: border-box;">2022年,蔡宗葦教授領(lǐng)導(dǎo)的研究小組發(fā)現(xiàn)三氯生重新激活導(dǎo)致結(jié)腸炎機(jī)制。</span></em></span></p> </section> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> <section style="text-align: justify; box-sizing: border-box;"> <p style="margin: 0px; padding: 0px; box-sizing: border-box;">&nbsp;</p> </section> </section> </section> </section> </section> </section> <p style="display: none;">&nbsp;</p> </section>
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